FIDELITY OF HUMAN OVARIAN CANCER PATIENT-DERIVED XENOGRAFTS IN A PARTIALLY HUMANIZED MOUSE MODEL FOR PRECLINICAL TESTING OF IMMUNOTHERAPIES

Fidelity of human ovarian cancer patient-derived xenografts in a partially humanized mouse model for preclinical testing of immunotherapies

Background Immune checkpoint blockers (ICBs) have been approved by the Food and Drug Administration to be used alone in front-line therapies or in combination with other regimens for certain advanced cancers.Since ICB only works in a subset of patients and has limited efficacy in treating ovarian cancer (OVC), developing preclinical models IBS RELI

read more

Effect of stimulus dimension on perception and cognition

Stimuli characteristics ha a decisive role in our perception and cognition.In the present study, we aimed to evaluate the effects of dimension of stimuli, two-dimensional (2D) versus three-dimensional (3D), on perception and working memory.In the first experiment, using the method of eye tracking, a higher blink rate, pupil size, and the number of

read more


Ethanol exposure interacts with training conditions to influence behavioral adaptation to a negative instrumental contingency

We previously reported that, in male, Long Evans rats, instrumental lever pressing that had been reinforced during limited training under a variable interval (VI) schedule by oral self-administration of a 10% sucrose/10% ethanol (10S10E) solution was insensitive to devaluation of 10S10E.In contrast, lever pressing that had been reinforced under a v

read more

Optimizing Multi-Modal Electromagnetic Design Problems Using Quantum Particle Swarm Optimization With Differential Evolution

Many versatile and promising swarm intelligence evolutionary algorithms are being developed to solve engineering optimization problems.Although evolutionary algorithms have been implemented in various optimization fields, there is still potential for enhancement in the domain of complex, electromagnetic, and Bubble Toy multimodal objective problems

read more